MATHEMATICAL MODELING IN PATHOPHYSIOLOGY (FISIOMAT)

Coordinator: Simona Panunzi

Description

The research program of the FISIOMAT group is distinguished into two complementary lines of research: Translational and Precision Medicine applied to Endocrine, Oncological, and Neurological Pathologies The research activity is mainly based on the individual variability of the genome, the environment, and the lifestyle. The goal is to redesign protocols for disease prevention, diagnosis, and treatment with state-of-the-art genomic methodologies integrated with methods and models for analyzing biomedical systems in a highly multidisciplinary approach. Clinical and Experimental Pathophysiology and Mathematical Modeling in Physiology and Pathophysiology The research activity is aimed at developing a quantitative understanding of phenomena related in general to life sciences (pathophysiology, metabolism, and epidemiology) through an interdisciplinary approach that makes use of modeling, qualitative analysis, numerical simulation, and statistical parameter estimation. Models

1. Ex vivo experimental models representative of human pathologies (i.e., prostate, pancreatic, and thyroid cancer, pituitary adenomas)
2. Experimental human-derived (iPSCs, brain organoids) and animal models of human pathologies (i.e., Alzheimer, amyotrophic lateral sclerosis, pancreatic carcinoma)
3. Biomathematical models (i.e., energy metabolism, cardiovascular system, decision support in medicine, tumor growth)
4. Mathematical modeling web services for the use of models also in M2M (machine-to-machine) modality