PNRRFARSE
- Post by: stefano_lusetti
- 16 Maggio 2023
- Comments off
Spoke_2_Centro Nazionale_Sviluppo di terapia genica e farmaci con tecnologia a RNA_IASIResearch group: FISIOMAT
Project leader: Antonella FarsettiUrl progetto: https://www.mur.gov.it/it/news/mercoledi-15062022/pnrr-nascono-i-5-centri-nazionali-la-ricerca
The project is focused on the clinical development of RNA AntiSense Oligonucleotides (ASO) targeting noncoding-RNAs, mainly applied to solid cancers. Specifically, our activity will develop and optimize RNA therapeutics, e.g., MALAT1 gapmers or miRNA mimic synthetic products or ASO-anti-miRNAs for the miR200 family. The experimental design includes a combination of ASO approach plus selective small molecules, e.g. new HSP90 inhibitors or epigenetic drugs or nuclear hormone receptor modulators
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